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Complement Deficiencies v2.0 FCN3 Gene migrated from ENSG00000142748 to ENSG00000142748 (gene set migration)
Complement Deficiencies v2.0 THBD Gene migrated from ENSG00000178726 to ENSG00000178726 (gene set migration)
Complement Deficiencies v2.0 ITGAM Gene migrated from ENSG00000169896 to ENSG00000169896 (gene set migration)
Complement Deficiencies v2.0 CFHR4 Gene migrated from ENSG00000134365 to ENSG00000134365 (gene set migration)
Complement Deficiencies v2.0 C8G Gene migrated from ENSG00000176919 to ENSG00000176919 (gene set migration)
Complement Deficiencies v2.0 MASP2 Gene migrated from ENSG00000009724 to ENSG00000009724 (gene set migration)
Complement Deficiencies v2.0 C8A Gene migrated from ENSG00000157131 to ENSG00000157131 (gene set migration)
Complement Deficiencies v2.0 C4B Gene migrated from ENSG00000224389 to ENSG00000224389 (gene set migration)
Complement Deficiencies v2.0 C4A Gene migrated from ENSG00000244731 to ENSG00000244731 (gene set migration)
Complement Deficiencies v2.0 C6 Gene migrated from ENSG00000039537 to ENSG00000039537 (gene set migration)
Complement Deficiencies v2.0 C5 Gene migrated from ENSG00000106804 to ENSG00000106804 (gene set migration)
Complement Deficiencies v2.0 C3 Gene migrated from ENSG00000125730 to ENSG00000125730 (gene set migration)
Complement Deficiencies v2.0 C1S Gene migrated from ENSG00000182326 to ENSG00000182326 (gene set migration)
Complement Deficiencies v2.0 C1QC Gene migrated from ENSG00000159189 to ENSG00000159189 (gene set migration)
Complement Deficiencies v2.0 CFD Gene migrated from ENSG00000197766 to ENSG00000197766 (gene set migration)
Complement Deficiencies v2.0 CD59 Gene migrated from ENSG00000085063 to ENSG00000085063 (gene set migration)
Complement Deficiencies v2.0 C1QB Gene migrated from ENSG00000173369 to ENSG00000173369 (gene set migration)
Complement Deficiencies v2.0 CD46 Gene migrated from ENSG00000117335 to ENSG00000117335 (gene set migration)
Complement Deficiencies v2.0 C2 Gene migrated from ENSG00000166278 to ENSG00000166278 (gene set migration)
Complement Deficiencies v2.0 C1QA Gene migrated from ENSG00000173372 to ENSG00000173372 (gene set migration)
Complement Deficiencies v2.0 CD55 Gene migrated from ENSG00000196352 to ENSG00000196352 (gene set migration)
Complement Deficiencies v2.0 C1R Gene migrated from ENSG00000159403 to ENSG00000159403 (gene set migration)
Complement Deficiencies v2.0 CFI Gene migrated from ENSG00000205403 to ENSG00000205403 (gene set migration)
Complement Deficiencies v2.0 CFH Gene migrated from ENSG00000000971 to ENSG00000000971 (gene set migration)
Complement Deficiencies v2.0 SERPING1 Gene migrated from ENSG00000149131 to ENSG00000149131 (gene set migration)
Complement Deficiencies v2.0 CFP Gene migrated from ENSG00000126759 to ENSG00000126759 (gene set migration)
Complement Deficiencies v2.0 C9 Gene migrated from ENSG00000113600 to ENSG00000113600 (gene set migration)
Complement Deficiencies v2.0 C8B Gene migrated from ENSG00000021852 to ENSG00000021852 (gene set migration)
Complement Deficiencies v2.0 C7 Gene migrated from ENSG00000112936 to ENSG00000112936 (gene set migration)
Complement Deficiencies v2.0 CFHR2 Gene migrated from ENSG00000080910 to ENSG00000080910 (gene set migration)
Complement Deficiencies v2.0 CFB Gene migrated from ENSG00000243649 to ENSG00000243649 (gene set migration)
Complement Deficiencies v2.0 CFHR5 Gene migrated from ENSG00000134389 to ENSG00000134389 (gene set migration)
Complement Deficiencies v2.0 CFHR3 Gene migrated from ENSG00000116785 to ENSG00000116785 (gene set migration)
Complement Deficiencies v2.0 CFHR1 Gene migrated from ENSG00000244414 to ENSG00000244414 (gene set migration)
Complement Deficiencies v2.0 Panel migrated to gene set Ensemblv115. Source version: v1.2
Complement Deficiencies v1.2 THBD Chirag Patel Tag disputed tag was added to gene: THBD.
Complement Deficiencies v1.2 THBD Chirag Patel reviewed gene: THBD: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Complement Deficiencies v1.2 FCN3 Zornitza Stark Classified gene: FCN3 as Red List (low evidence)
Complement Deficiencies v1.2 FCN3 Zornitza Stark Gene: fcn3 has been classified as Red List (Low Evidence).
Complement Deficiencies v1.2 FCN3 Zornitza Stark Classified gene: FCN3 as Red List (low evidence)
Complement Deficiencies v1.2 FCN3 Zornitza Stark Gene: fcn3 has been classified as Red List (Low Evidence).
Complement Deficiencies v1.1 FCN3 Zornitza Stark edited their review of gene: FCN3: Added comment: Same hmz variant in all reported cases, some discussion in the literature about whether this is a genuine gene-disease association, downgrade to Red.; Changed rating: RED
Complement Deficiencies v1.1 C4A Zornitza Stark Publications for gene: C4A were set to 22387014; 22737222; 15998580; 10529130; 15294999; 32048120
Complement Deficiencies v1.0 C4A Zornitza Stark reviewed gene: C4A: Rating: AMBER; Mode of pathogenicity: None; Publications: 40788338; Phenotypes: C4a deficiency MIM#614380; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v1.0 Bryony Thompson promoted panel to version 1.0
Complement Deficiencies v0.87 Bryony Thompson Panel types changed to Melbourne Genomics; Victorian Clinical Genetics Services; Royal Melbourne Hospital; Rare Disease
Complement Deficiencies v0.86 THBD Bryony Thompson Deleted their review
Complement Deficiencies v0.86 CFHR5 Bryony Thompson Mode of inheritance for gene: CFHR5 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Complement Deficiencies v0.85 CFHR5 Bryony Thompson Classified gene: CFHR5 as Green List (high evidence)
Complement Deficiencies v0.85 CFHR5 Bryony Thompson Added comment: Comment on list classification: IUIS include this gene on their July 2024 list of inborn errors of immunology
Complement Deficiencies v0.85 CFHR5 Bryony Thompson Gene: cfhr5 has been classified as Green List (High Evidence).
Complement Deficiencies v0.84 CFHR3 Bryony Thompson Publications for gene: CFHR3 were set to
Complement Deficiencies v0.83 CFHR3 Bryony Thompson Classified gene: CFHR3 as Green List (high evidence)
Complement Deficiencies v0.83 CFHR3 Bryony Thompson Added comment: Comment on list classification: IUIS include this gene on their July 2024 list of inborn errors of immunology
Complement Deficiencies v0.83 CFHR3 Bryony Thompson Gene: cfhr3 has been classified as Green List (High Evidence).
Complement Deficiencies v0.82 CFHR2 Bryony Thompson Classified gene: CFHR2 as Green List (high evidence)
Complement Deficiencies v0.82 CFHR2 Bryony Thompson Added comment: Comment on list classification: IUIS include this gene on their July 2024 list of inborn errors of immunology
Complement Deficiencies v0.82 CFHR2 Bryony Thompson Gene: cfhr2 has been classified as Green List (High Evidence).
Complement Deficiencies v0.81 CFHR1 Bryony Thompson Publications for gene: CFHR1 were set to
Complement Deficiencies v0.80 CFHR1 Bryony Thompson Mode of inheritance for gene: CFHR1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.79 CFHR1 Bryony Thompson Classified gene: CFHR1 as Green List (high evidence)
Complement Deficiencies v0.79 CFHR1 Bryony Thompson Added comment: Comment on list classification: IUIS include this gene on their July 2024 list of inborn errors of immunology
Complement Deficiencies v0.79 CFHR1 Bryony Thompson Gene: cfhr1 has been classified as Green List (High Evidence).
Complement Deficiencies v0.78 CFB Bryony Thompson Phenotypes for gene: CFB were changed from Complement factor B deficiency, MIM# 615561 to complement factor b deficiency MONDO:0014255; Atypical hemolytic-uremic syndrome with B factor anomaly MONDO:0013042
Complement Deficiencies v0.77 CFB Bryony Thompson edited their review of gene: CFB: Changed phenotypes: complement factor b deficiency MONDO:0014255, Atypical hemolytic-uremic syndrome with B factor anomaly MONDO:0013042
Complement Deficiencies v0.77 CFB Bryony Thompson Publications for gene: CFB were set to 24152280
Complement Deficiencies v0.76 CFB Bryony Thompson Mode of inheritance for gene: CFB was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.75 CFB Bryony Thompson Classified gene: CFB as Green List (high evidence)
Complement Deficiencies v0.75 CFB Bryony Thompson Gene: cfb has been classified as Green List (High Evidence).
Complement Deficiencies v0.74 CFB Bryony Thompson reviewed gene: CFB: Rating: GREEN; Mode of pathogenicity: None; Publications: 33165708, 24152280, 17182750; Phenotypes: complement factor b deficiency MONDO:0014255; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.73 CFB Zornitza Stark Marked gene: CFB as ready
Complement Deficiencies v0.73 CFB Zornitza Stark Gene: cfb has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.73 Zornitza Stark HPO terms changed from to Abnormality of complement system, HP:0005339
List of related panels changed from to Abnormality of complement system; HP:0005339
Complement Deficiencies v0.72 C6 Zornitza Stark Tag treatable tag was added to gene: C6.
Complement Deficiencies v0.72 C5 Crystle Lee reviewed gene: C5: Rating: AMBER; Mode of pathogenicity: None; Publications: 31440263, 23743184, 15488949, 15778377, 23371790; Phenotypes: C5 deficiency (MIM#609536); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.72 C8A Zornitza Stark Marked gene: C8A as ready
Complement Deficiencies v0.72 C8A Zornitza Stark Gene: c8a has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.72 C8A Zornitza Stark Phenotypes for gene: C8A were changed from to C8 deficiency, type I MIM#613790
Complement Deficiencies v0.71 C8A Zornitza Stark Publications for gene: C8A were set to
Complement Deficiencies v0.70 C8A Zornitza Stark Mode of inheritance for gene: C8A was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.69 C8A Zornitza Stark Classified gene: C8A as Amber List (moderate evidence)
Complement Deficiencies v0.69 C8A Zornitza Stark Gene: c8a has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.68 C8A Zornitza Stark reviewed gene: C8A: Rating: AMBER; Mode of pathogenicity: None; Publications: 9759902, 32769119; Phenotypes: C8 deficiency, type I MIM#613790; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.68 C4A Ain Roesley edited their review of gene: C4A: Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.68 C4A Ain Roesley Mode of inheritance for gene: C4A was changed from Other to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.67 C4B Zornitza Stark Tag for review was removed from gene: C4B.
Complement Deficiencies v0.67 C4B Ain Roesley Mode of inheritance for gene: C4B was changed from Other to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.66 C4B Ain Roesley edited their review of gene: C4B: Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.66 C4A Ain Roesley Phenotypes for gene: C4A were changed from C4a deficiency MIM#614380; susceptibility systemic lupus erythematosus to C4a deficiency MIM#614380; susceptibility systemic lupus erythematosus
Complement Deficiencies v0.66 C4A Ain Roesley Mode of inheritance for gene: C4A was changed from Other to Other
Complement Deficiencies v0.65 C4A Ain Roesley Phenotypes for gene: C4A were changed from C4a deficiency MIM#614380; susceptibility systemic lupus erythematosus to C4a deficiency MIM#614380; susceptibility systemic lupus erythematosus
Complement Deficiencies v0.66 C4A Ain Roesley Mode of inheritance for gene: C4A was changed from Other to Other
Complement Deficiencies v0.66 C4A Ain Roesley Tag SV/CNV tag was added to gene: C4A.
Complement Deficiencies v0.66 C4A Ain Roesley Phenotypes for gene: C4A were changed from to C4a deficiency MIM#614380; susceptibility systemic lupus erythematosus
Complement Deficiencies v0.65 C4A Ain Roesley Publications for gene: C4A were set to
Complement Deficiencies v0.65 C4A Ain Roesley Mode of inheritance for gene: C4A was changed from Unknown to Other
Complement Deficiencies v0.65 C4A Ain Roesley Classified gene: C4A as Amber List (moderate evidence)
Complement Deficiencies v0.65 C4A Ain Roesley Gene: c4a has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.64 C4A Ain Roesley Marked gene: C4A as ready
Complement Deficiencies v0.64 C4A Ain Roesley Gene: c4a has been classified as Green List (High Evidence).
Complement Deficiencies v0.64 C4A Ain Roesley edited their review of gene: C4A: Changed rating: AMBER
Complement Deficiencies v0.64 C4A Ain Roesley edited their review of gene: C4A: Changed publications: 22387014, 22737222, 15998580, 10529130, 15294999, 32048120
Complement Deficiencies v0.64 C4A Ain Roesley changed review comment from: Associated with increased risk for systemic lupus erythematosus (SLE).
This is mostly involving haplotypes, gene copy number, gene conversions with/without C4B; to: Associated with increased risk for systemic lupus erythematosus (SLE).
This is mostly involving haplotypes, gene copy number, gene conversions with/without C4B

There are no LP/P SNV in clinvar

PMID: 32048120;
2019 Update of the IUIS Phenotypical Classification indicates that complete C4 deficiency requires both C4A+C4B and C4A alone leads to partial deficiency
Complement Deficiencies v0.64 C4B Ain Roesley Mode of inheritance for gene: C4B was changed from Other to Other
Complement Deficiencies v0.63 C4B Ain Roesley Phenotypes for gene: C4B were changed from to susceptibility to autoimmune disease; C4B deficiency MIM#614379
Complement Deficiencies v0.63 C4B Ain Roesley Publications for gene: C4B were set to
Complement Deficiencies v0.63 C4B Ain Roesley Mode of inheritance for gene: C4B was changed from Unknown to Other
Complement Deficiencies v0.63 C4B Ain Roesley Marked gene: C4B as ready
Complement Deficiencies v0.63 C4B Ain Roesley Gene: c4b has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.63 C4B Ain Roesley Tag SV/CNV tag was added to gene: C4B.
Complement Deficiencies v0.63 C4B Ain Roesley Classified gene: C4B as Amber List (moderate evidence)
Complement Deficiencies v0.63 C4B Ain Roesley Gene: c4b has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.62 C4B Ain Roesley edited their review of gene: C4B: Changed rating: AMBER
Complement Deficiencies v0.62 C4B Ain Roesley edited their review of gene: C4B: Changed publications: 34764957, 12626442, 22387014, 17503323, 32048120
Complement Deficiencies v0.62 C4B Ain Roesley changed review comment from: Associated with increased risk for systemic lupus erythematosus (SLE).
This is mostly involving haplotypes, gene copy number, gene conversions with/without C4A; to: Associated with increased risk for systemic lupus erythematosus (SLE).
This is mostly involving haplotypes, gene copy number, gene conversions with/without C4A

no LP/P SNVs in clinvar. (1 LP but evidence provided indicates that it was classified as a VUS)

PMID: 32048120;
2019 Update of the IUIS Phenotypical Classification indicates that complete C4 deficiency requires both C4A+C4B and C4B alone leads to partial deficiency
Complement Deficiencies v0.62 C9 Ain Roesley Marked gene: C9 as ready
Complement Deficiencies v0.62 C9 Ain Roesley Gene: c9 has been classified as Green List (High Evidence).
Complement Deficiencies v0.62 C9 Ain Roesley Phenotypes for gene: C9 were changed from to C9 deficiency MIM#613825
Complement Deficiencies v0.61 C9 Ain Roesley Publications for gene: C9 were set to
Complement Deficiencies v0.60 C9 Ain Roesley Mode of inheritance for gene: C9 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.59 C9 Ain Roesley reviewed gene: C9: Rating: GREEN; Mode of pathogenicity: None; Publications: 9570574, 9703418, 9144525, 31440263, 9634479; Phenotypes: C9 deficiency MIM#613825; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.59 C8B Ain Roesley Marked gene: C8B as ready
Complement Deficiencies v0.59 C8B Ain Roesley Gene: c8b has been classified as Green List (High Evidence).
Complement Deficiencies v0.59 C8B Ain Roesley Phenotypes for gene: C8B were changed from to C8 deficiency, type II MIM#613789
Complement Deficiencies v0.58 C8B Ain Roesley Mode of inheritance for gene: C8B was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.57 C8B Ain Roesley reviewed gene: C8B: Rating: GREEN; Mode of pathogenicity: None; Publications: 8098723, 33563058, 27183977, 9476133, 19434484; Phenotypes: C8 deficiency, type II MIM#613789; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.57 C7 Ain Roesley Marked gene: C7 as ready
Complement Deficiencies v0.57 C7 Ain Roesley Gene: c7 has been classified as Green List (High Evidence).
Complement Deficiencies v0.57 C7 Ain Roesley Phenotypes for gene: C7 were changed from to C7 deficiency MIM#610102
Complement Deficiencies v0.56 C7 Ain Roesley Publications for gene: C7 were set to 22206826; 20591074; 17407100; 16771861; 16552475
Complement Deficiencies v0.56 C7 Ain Roesley Publications for gene: C7 were set to
Complement Deficiencies v0.55 C7 Ain Roesley Mode of inheritance for gene: C7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.54 C7 Ain Roesley reviewed gene: C7: Rating: GREEN; Mode of pathogenicity: None; Publications: 22206826, 20591074, 17407100, 16771861, 16552475; Phenotypes: C7 deficiency MIM#610102; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.54 C6 Ain Roesley Publications for gene: C6 were set to 23537992; 24378253; 17257682; 22668955; 32670577
Complement Deficiencies v0.53 C6 Ain Roesley Mode of inheritance for gene: C6 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.53 C6 Ain Roesley Publications for gene: C6 were set to 23537992; 24378253; 17257682; 22668955; 32670577
Complement Deficiencies v0.53 C6 Ain Roesley Phenotypes for gene: C6 were changed from to C6 deficiency MIM#612446
Complement Deficiencies v0.53 C6 Ain Roesley Publications for gene: C6 were set to
Complement Deficiencies v0.53 C6 Ain Roesley Mode of inheritance for gene: C6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.52 C6 Ain Roesley Marked gene: C6 as ready
Complement Deficiencies v0.52 C6 Ain Roesley Gene: c6 has been classified as Green List (High Evidence).
Complement Deficiencies v0.52 C6 Ain Roesley reviewed gene: C6: Rating: GREEN; Mode of pathogenicity: None; Publications: 23537992, 24378253, 17257682, 22668955, 32670577; Phenotypes: C6 deficiency MIM#612446; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.52 C5 Ain Roesley Phenotypes for gene: C5 were changed from C5 deficiency MIM#609536 to C5 deficiency MIM#609536
Complement Deficiencies v0.51 C5 Ain Roesley Mode of inheritance for gene: C5 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.51 C5 Ain Roesley Publications for gene: C5 were set to 23743184; 15488949; 15778377; 23371790
Complement Deficiencies v0.50 C5 Ain Roesley Publications for gene: C5 were set to
Complement Deficiencies v0.50 C5 Ain Roesley Phenotypes for gene: C5 were changed from to C5 deficiency MIM#609536
Complement Deficiencies v0.50 C5 Ain Roesley Mode of inheritance for gene: C5 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.50 C5 Ain Roesley Mode of pathogenicity for gene: C5 was changed from to None
Complement Deficiencies v0.50 C5 Ain Roesley Mode of inheritance for gene: C5 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.49 C5 Ain Roesley Marked gene: C5 as ready
Complement Deficiencies v0.49 C5 Ain Roesley Gene: c5 has been classified as Green List (High Evidence).
Complement Deficiencies v0.49 C5 Ain Roesley reviewed gene: C5: Rating: GREEN; Mode of pathogenicity: None; Publications: 23743184, 15488949, 15778377, 23371790; Phenotypes: C5 deficiency MIM#609536; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.49 C4A Ain Roesley reviewed gene: C4A: Rating: RED; Mode of pathogenicity: None; Publications: 22387014, 22737222, 15998580, 10529130, 15294999; Phenotypes: C4a deficiency MIM#614380, susceptibility systemic lupus erythematosus; Mode of inheritance: Other; Current diagnostic: yes
Complement Deficiencies v0.49 C4B Ain Roesley reviewed gene: C4B: Rating: RED; Mode of pathogenicity: None; Publications: 34764957, 12626442, 22387014, 17503323; Phenotypes: susceptibility to autoimmune disease, C4B deficiency MIM#614379; Mode of inheritance: Other; Current diagnostic: yes
Complement Deficiencies v0.49 C3 Ain Roesley Phenotypes for gene: C3 were changed from C3 deficiency MIM#613779 to C3 deficiency MIM#613779
Complement Deficiencies v0.49 C3 Ain Roesley Publications for gene: C3 were set to 15781264; 1944729; 11813855; 26847111
Complement Deficiencies v0.48 C3 Ain Roesley Phenotypes for gene: C3 were changed from to C3 deficiency MIM#613779
Complement Deficiencies v0.48 C3 Ain Roesley Publications for gene: C3 were set to
Complement Deficiencies v0.48 C3 Ain Roesley Mode of pathogenicity for gene: C3 was changed from to None
Complement Deficiencies v0.48 C3 Ain Roesley Marked gene: C3 as ready
Complement Deficiencies v0.48 C3 Ain Roesley Gene: c3 has been classified as Green List (High Evidence).
Complement Deficiencies v0.48 C3 Ain Roesley Mode of inheritance for gene: C3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.47 C3 Ain Roesley reviewed gene: C3: Rating: GREEN; Mode of pathogenicity: None; Publications: 15781264, 1944729, 11813855, 26847111; Phenotypes: C3 deficiency MIM#613779; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.47 C1S Ain Roesley Phenotypes for gene: C1S were changed from to C1s deficiency MIM#613783
Complement Deficiencies v0.47 C1S Ain Roesley Publications for gene: C1S were set to
Complement Deficiencies v0.47 C1S Ain Roesley Mode of inheritance for gene: C1S was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.46 C1S Ain Roesley Marked gene: C1S as ready
Complement Deficiencies v0.46 C1S Ain Roesley Gene: c1s has been classified as Green List (High Evidence).
Complement Deficiencies v0.46 C1S Ain Roesley reviewed gene: C1S: Rating: GREEN; Mode of pathogenicity: None; Publications: 19155518, 20191570, 18062908, 11390518, 9856483; Phenotypes: C1s deficiency MIM#613783; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.46 C1QC Ain Roesley edited their review of gene: C1QC: Changed publications: 21654842, 8630118, 24157463
Complement Deficiencies v0.46 C1QC Ain Roesley Marked gene: C1QC as ready
Complement Deficiencies v0.46 C1QC Ain Roesley Gene: c1qc has been classified as Green List (High Evidence).
Complement Deficiencies v0.46 C1QC Ain Roesley Publications for gene: C1QC were set to
Complement Deficiencies v0.45 C1QC Ain Roesley Phenotypes for gene: C1QC were changed from to C1q deficiency MIM#613652
Complement Deficiencies v0.45 C1QC Ain Roesley Mode of inheritance for gene: C1QC was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.44 C1QC Ain Roesley reviewed gene: C1QC: Rating: GREEN; Mode of pathogenicity: None; Publications: 8630118; Phenotypes: C1q deficiency MIM#613652; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Complement Deficiencies v0.44 MASP2 Bryony Thompson Publications for gene: MASP2 were set to
Complement Deficiencies v0.43 C1QB Zornitza Stark Marked gene: C1QB as ready
Complement Deficiencies v0.43 C1QB Zornitza Stark Gene: c1qb has been classified as Green List (High Evidence).
Complement Deficiencies v0.43 C1QB Zornitza Stark Phenotypes for gene: C1QB were changed from to C1q deficiency, MIM# 613652
Complement Deficiencies v0.42 C1QB Zornitza Stark Publications for gene: C1QB were set to 2894352; 17513176
Complement Deficiencies v0.42 C1QB Zornitza Stark Publications for gene: C1QB were set to
Complement Deficiencies v0.41 C1QB Zornitza Stark Mode of inheritance for gene: C1QB was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.40 C1QB Zornitza Stark reviewed gene: C1QB: Rating: GREEN; Mode of pathogenicity: None; Publications: 2894352, 17513176; Phenotypes: C1q deficiency, MIM# 613652; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.40 C1QA Zornitza Stark Marked gene: C1QA as ready
Complement Deficiencies v0.40 C1QA Zornitza Stark Gene: c1qa has been classified as Green List (High Evidence).
Complement Deficiencies v0.40 C1QA Zornitza Stark Phenotypes for gene: C1QA were changed from to C1q deficiency, MIM# 613652
Complement Deficiencies v0.39 C1QA Zornitza Stark Publications for gene: C1QA were set to
Complement Deficiencies v0.38 C1QA Zornitza Stark Mode of inheritance for gene: C1QA was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.37 C1QA Zornitza Stark Mode of inheritance for gene: C1QA was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.36 C1QA Zornitza Stark reviewed gene: C1QA: Rating: GREEN; Mode of pathogenicity: None; Publications: 9225968, 21654842, 9590289; Phenotypes: C1q deficiency, MIM# 613652; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.36 C4A Bryony Thompson Tag for review tag was added to gene: C4A.
Complement Deficiencies v0.36 C4B Bryony Thompson Tag for review tag was added to gene: C4B.
Complement Deficiencies v0.35 THBD Zornitza Stark Marked gene: THBD as ready
Complement Deficiencies v0.35 THBD Zornitza Stark Gene: thbd has been classified as Red List (Low Evidence).
Complement Deficiencies v0.35 THBD Zornitza Stark Phenotypes for gene: THBD were changed from to {Hemolytic uremic syndrome, atypical, susceptibility to, 6}, MIM# 612926
Complement Deficiencies v0.34 THBD Zornitza Stark Publications for gene: THBD were set to
Complement Deficiencies v0.33 THBD Zornitza Stark Mode of inheritance for gene: THBD was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Complement Deficiencies v0.32 THBD Zornitza Stark Classified gene: THBD as Red List (low evidence)
Complement Deficiencies v0.32 THBD Zornitza Stark Gene: thbd has been classified as Red List (Low Evidence).
Complement Deficiencies v0.31 THBD Zornitza Stark reviewed gene: THBD: Rating: RED; Mode of pathogenicity: None; Publications: 29500241, 19625716; Phenotypes: {Hemolytic uremic syndrome, atypical, susceptibility to, 6}, MIM# 612926; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Complement Deficiencies v0.31 MASP2 Zornitza Stark Marked gene: MASP2 as ready
Complement Deficiencies v0.31 MASP2 Zornitza Stark Gene: masp2 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.31 MASP2 Zornitza Stark Phenotypes for gene: MASP2 were changed from to MASP2 deficiency, MIM# 613791
Complement Deficiencies v0.30 MASP2 Zornitza Stark Mode of inheritance for gene: MASP2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.29 MASP2 Zornitza Stark Classified gene: MASP2 as Red List (low evidence)
Complement Deficiencies v0.29 MASP2 Zornitza Stark Gene: masp2 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.28 MASP2 Zornitza Stark reviewed gene: MASP2: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: MASP2 deficiency, MIM# 613791; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.28 ITGAM Zornitza Stark Marked gene: ITGAM as ready
Complement Deficiencies v0.28 ITGAM Zornitza Stark Gene: itgam has been classified as Red List (Low Evidence).
Complement Deficiencies v0.28 ITGAM Zornitza Stark Classified gene: ITGAM as Red List (low evidence)
Complement Deficiencies v0.28 ITGAM Zornitza Stark Gene: itgam has been classified as Red List (Low Evidence).
Complement Deficiencies v0.27 ITGAM Zornitza Stark reviewed gene: ITGAM: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Complement Deficiencies v0.27 FCN3 Zornitza Stark Marked gene: FCN3 as ready
Complement Deficiencies v0.27 FCN3 Zornitza Stark Gene: fcn3 has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.27 FCN3 Zornitza Stark Phenotypes for gene: FCN3 were changed from to Immunodeficiency due to ficolin 3 deficiency, MIM# 613860
Complement Deficiencies v0.26 FCN3 Zornitza Stark Publications for gene: FCN3 were set to
Complement Deficiencies v0.25 FCN3 Zornitza Stark Mode of inheritance for gene: FCN3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.24 FCN3 Zornitza Stark Classified gene: FCN3 as Amber List (moderate evidence)
Complement Deficiencies v0.24 FCN3 Zornitza Stark Gene: fcn3 has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.23 FCN3 Zornitza Stark reviewed gene: FCN3: Rating: AMBER; Mode of pathogenicity: None; Publications: 25662573, 22226667, 19535802, 20971976; Phenotypes: Immunodeficiency due to ficolin 3 deficiency, MIM# 613860; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.23 CFHR5 Zornitza Stark Marked gene: CFHR5 as ready
Complement Deficiencies v0.23 CFHR5 Zornitza Stark Gene: cfhr5 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.23 CFHR5 Zornitza Stark Phenotypes for gene: CFHR5 were changed from to Nephropathy due to CFHR5 deficiency, MIM# 614809
Complement Deficiencies v0.22 CFHR5 Zornitza Stark Classified gene: CFHR5 as Red List (low evidence)
Complement Deficiencies v0.22 CFHR5 Zornitza Stark Gene: cfhr5 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.21 CFHR5 Zornitza Stark reviewed gene: CFHR5: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Nephropathy due to CFHR5 deficiency, MIM# 614809; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Complement Deficiencies v0.21 CFHR4 Zornitza Stark Marked gene: CFHR4 as ready
Complement Deficiencies v0.21 CFHR4 Zornitza Stark Gene: cfhr4 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.21 CFHR4 Zornitza Stark Classified gene: CFHR4 as Red List (low evidence)
Complement Deficiencies v0.21 CFHR4 Zornitza Stark Gene: cfhr4 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.20 CFHR4 Zornitza Stark changed review comment from: Association is with aHUS, gene is on aHUS panel.; to: No Mendelian gene disease association I can find.
Complement Deficiencies v0.20 CFHR4 Zornitza Stark reviewed gene: CFHR4: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Susceptibility to atypical haemolytic uraemic syndrome; Mode of inheritance: None
Complement Deficiencies v0.20 CFHR3 Zornitza Stark Marked gene: CFHR3 as ready
Complement Deficiencies v0.20 CFHR3 Zornitza Stark Gene: cfhr3 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.20 CFHR3 Zornitza Stark Phenotypes for gene: CFHR3 were changed from to {Hemolytic uremic syndrome, atypical, susceptibility to}, MIM# 235400
Complement Deficiencies v0.19 CFHR3 Zornitza Stark Mode of inheritance for gene: CFHR3 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.18 CFHR3 Zornitza Stark Classified gene: CFHR3 as Red List (low evidence)
Complement Deficiencies v0.18 CFHR3 Zornitza Stark Gene: cfhr3 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.17 CFHR3 Zornitza Stark reviewed gene: CFHR3: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: {Hemolytic uremic syndrome, atypical, susceptibility to}, MIM# 235400; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.17 CFHR2 Zornitza Stark Tag SV/CNV tag was added to gene: CFHR2.
Complement Deficiencies v0.17 CFHR2 Zornitza Stark Marked gene: CFHR2 as ready
Complement Deficiencies v0.17 CFHR2 Zornitza Stark Gene: cfhr2 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.17 CFHR2 Zornitza Stark Phenotypes for gene: CFHR2 were changed from to C3 glomerulopathy; C3G; Immune complex MPGN; IC-MPGN
Complement Deficiencies v0.16 CFHR2 Zornitza Stark Publications for gene: CFHR2 were set to
Complement Deficiencies v0.15 CFHR2 Zornitza Stark Mode of inheritance for gene: CFHR2 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.14 CFHR2 Zornitza Stark Classified gene: CFHR2 as Red List (low evidence)
Complement Deficiencies v0.14 CFHR2 Zornitza Stark Gene: cfhr2 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.13 CFHR2 Zornitza Stark reviewed gene: CFHR2: Rating: RED; Mode of pathogenicity: None; Publications: 24334459, 23728178, 20800271; Phenotypes: C3 glomerulopathy, C3G, Immune complex MPGN, IC-MPGN; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Complement Deficiencies v0.13 CFHR1 Zornitza Stark Marked gene: CFHR1 as ready
Complement Deficiencies v0.13 CFHR1 Zornitza Stark Gene: cfhr1 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.13 CFHR1 Zornitza Stark Classified gene: CFHR1 as Red List (low evidence)
Complement Deficiencies v0.13 CFHR1 Zornitza Stark Gene: cfhr1 has been classified as Red List (Low Evidence).
Complement Deficiencies v0.12 CFHR1 Zornitza Stark reviewed gene: CFHR1: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Complement Deficiencies v0.12 CFB Zornitza Stark Phenotypes for gene: CFB were changed from to Complement factor B deficiency, MIM# 615561
Complement Deficiencies v0.11 CFB Zornitza Stark Publications for gene: CFB were set to
Complement Deficiencies v0.10 CFB Zornitza Stark Mode of inheritance for gene: CFB was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.9 CFB Zornitza Stark Classified gene: CFB as Amber List (moderate evidence)
Complement Deficiencies v0.9 CFB Zornitza Stark Gene: cfb has been classified as Amber List (Moderate Evidence).
Complement Deficiencies v0.8 CFB Zornitza Stark reviewed gene: CFB: Rating: AMBER; Mode of pathogenicity: None; Publications: 24152280; Phenotypes: Complement factor B deficiency, MIM# 615561; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Complement Deficiencies v0.8 C8G Zornitza Stark Marked gene: C8G as ready
Complement Deficiencies v0.8 C8G Zornitza Stark Gene: c8g has been classified as Red List (Low Evidence).
Complement Deficiencies v0.8 C8G Zornitza Stark Classified gene: C8G as Red List (low evidence)
Complement Deficiencies v0.8 C8G Zornitza Stark Gene: c8g has been classified as Red List (Low Evidence).
Complement Deficiencies v0.7 C8G Zornitza Stark reviewed gene: C8G: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Complement Deficiencies v0.7 Zornitza Stark Panel name changed from Complement deficiencies to Complement Deficiencies
Panel types changed to Melbourne Genomics; Victorian Clinical Genetics Services; Rare Disease
Complement Deficiencies v0.6 Zornitza Stark Panel name changed from Complement deficiencies_MelbourneGenomics_VCGS to Complement deficiencies
Panel types changed to Victorian Clinical Genetics Services; Melbourne Genomics
Complement Deficiencies v0.5 CD55 Zornitza Stark Marked gene: CD55 as ready
Complement Deficiencies v0.5 CD55 Zornitza Stark Gene: cd55 has been classified as Green List (High Evidence).
Complement Deficiencies v0.5 CD55 Zornitza Stark Classified gene: CD55 as Green List (high evidence)
Complement Deficiencies v0.5 CD55 Zornitza Stark Gene: cd55 has been classified as Green List (High Evidence).
Complement Deficiencies v0.4 CD55 Zornitza Stark gene: CD55 was added
gene: CD55 was added to Complement deficiencies_MelbourneGenomics_VCGS. Sources: Expert list
Mode of inheritance for gene: CD55 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: CD55 were set to 28657829; 28657861
Phenotypes for gene: CD55 were set to Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy, MIM# 226300
Review for gene: CD55 was set to GREEN
Added comment: Nine families reported.
Sources: Expert list
Complement Deficiencies v0.2 Zornitza Stark Panel name changed from Complement deficiencies_MGHA_AGHA_VCGS to Complement deficiencies_MelbourneGenomics_VCGS
Complement Deficiencies v0.0 THBD Zornitza Stark gene: THBD was added
gene: THBD was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: THBD was set to Unknown
Complement Deficiencies v0.0 SERPING1 Zornitza Stark gene: SERPING1 was added
gene: SERPING1 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: SERPING1 was set to Unknown
Complement Deficiencies v0.0 MASP2 Zornitza Stark gene: MASP2 was added
gene: MASP2 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: MASP2 was set to Unknown
Complement Deficiencies v0.0 ITGAM Zornitza Stark gene: ITGAM was added
gene: ITGAM was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: ITGAM was set to Unknown
Complement Deficiencies v0.0 FCN3 Zornitza Stark gene: FCN3 was added
gene: FCN3 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: FCN3 was set to Unknown
Complement Deficiencies v0.0 CFP Zornitza Stark gene: CFP was added
gene: CFP was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFP was set to Unknown
Complement Deficiencies v0.0 CFI Zornitza Stark gene: CFI was added
gene: CFI was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFI was set to Unknown
Complement Deficiencies v0.0 CFHR5 Zornitza Stark gene: CFHR5 was added
gene: CFHR5 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFHR5 was set to Unknown
Complement Deficiencies v0.0 CFHR4 Zornitza Stark gene: CFHR4 was added
gene: CFHR4 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFHR4 was set to Unknown
Complement Deficiencies v0.0 CFHR3 Zornitza Stark gene: CFHR3 was added
gene: CFHR3 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFHR3 was set to Unknown
Complement Deficiencies v0.0 CFHR2 Zornitza Stark gene: CFHR2 was added
gene: CFHR2 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFHR2 was set to Unknown
Complement Deficiencies v0.0 CFHR1 Zornitza Stark gene: CFHR1 was added
gene: CFHR1 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFHR1 was set to Unknown
Complement Deficiencies v0.0 CFH Zornitza Stark gene: CFH was added
gene: CFH was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFH was set to Unknown
Complement Deficiencies v0.0 CFD Zornitza Stark gene: CFD was added
gene: CFD was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFD was set to Unknown
Complement Deficiencies v0.0 CFB Zornitza Stark gene: CFB was added
gene: CFB was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CFB was set to Unknown
Complement Deficiencies v0.0 CD59 Zornitza Stark gene: CD59 was added
gene: CD59 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CD59 was set to Unknown
Complement Deficiencies v0.0 CD46 Zornitza Stark gene: CD46 was added
gene: CD46 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: CD46 was set to Unknown
Complement Deficiencies v0.0 C9 Zornitza Stark gene: C9 was added
gene: C9 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C9 was set to Unknown
Complement Deficiencies v0.0 C8G Zornitza Stark gene: C8G was added
gene: C8G was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C8G was set to Unknown
Complement Deficiencies v0.0 C8B Zornitza Stark gene: C8B was added
gene: C8B was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C8B was set to Unknown
Complement Deficiencies v0.0 C8A Zornitza Stark gene: C8A was added
gene: C8A was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C8A was set to Unknown
Complement Deficiencies v0.0 C7 Zornitza Stark gene: C7 was added
gene: C7 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C7 was set to Unknown
Complement Deficiencies v0.0 C6 Zornitza Stark gene: C6 was added
gene: C6 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C6 was set to Unknown
Complement Deficiencies v0.0 C5 Zornitza Stark gene: C5 was added
gene: C5 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C5 was set to Unknown
Complement Deficiencies v0.0 C4B Zornitza Stark gene: C4B was added
gene: C4B was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C4B was set to Unknown
Complement Deficiencies v0.0 C4A Zornitza Stark gene: C4A was added
gene: C4A was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C4A was set to Unknown
Complement Deficiencies v0.0 C3 Zornitza Stark gene: C3 was added
gene: C3 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C3 was set to Unknown
Complement Deficiencies v0.0 C2 Zornitza Stark gene: C2 was added
gene: C2 was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C2 was set to Unknown
Complement Deficiencies v0.0 C1S Zornitza Stark gene: C1S was added
gene: C1S was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C1S was set to Unknown
Complement Deficiencies v0.0 C1R Zornitza Stark gene: C1R was added
gene: C1R was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C1R was set to Unknown
Complement Deficiencies v0.0 C1QC Zornitza Stark gene: C1QC was added
gene: C1QC was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C1QC was set to Unknown
Complement Deficiencies v0.0 C1QB Zornitza Stark gene: C1QB was added
gene: C1QB was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C1QB was set to Unknown
Complement Deficiencies v0.0 C1QA Zornitza Stark gene: C1QA was added
gene: C1QA was added to Complement deficiencies_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship
Mode of inheritance for gene: C1QA was set to Unknown
Complement Deficiencies v0.0 Zornitza Stark Added panel Complement deficiencies_MGHA_AGHA_VCGS