PanelApp
  1. Genes and Genomic Entities
  2. MYH6

MYH6

myosin heavy chain 6
OMIM: 160710, ClinGen, DECIPHER

7 panels

Panel Reviews Mode of inheritance Details
7 panels

Green MYH6 in Congenital Heart Defect


Level 2: Cardiovascular disorders
Version 0.540

3 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • MYH-6 related congenital heart defects MONDO:0800442

Red MYH6 in Hypertrophic cardiomyopathy


Level 2: Cardiovascular disorders
Version 1.26

Component of the following Super Panels:

  • Adult Cardiac SuperPanel
  • Cardiomyopathy_Adult_SuperPanel

    		•  2 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services
    Phenotypes
    • Hypertrophic cardiomyopathy, MONDO:0005045
    Tags
    • disputed

    Green MYH6 in Mendeliome


    Version 1.4851

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Atrial septal defect 3 MIM#614089
    • MYH-6 related congenital heart defects MONDO:0800442
    • Cardiomyopathy, dilated, 1EE MIM#613252
    • Cardiomyopathy, hypertrophic, 14 MIM#613251
    • {Sick sinus syndrome 3} MIM#614090

    Red MYH6 in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.231

    		2 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • London South GLH
    • South West GLH
    • NHS GMS
    Phenotypes
    • Cardiomyopathy, familial hypertrophic, 14
    • Cardiomyopathy, dilated, 1EE

    Red MYH6 in Additional findings_Paediatric


    Level 2: Screening
    Version 0.280

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • BabySeq Category C gene
    Phenotypes
    • Cardiomyopathy, familial hypertrophic
    • Atrial septal defect
    • Cardiomyopathy, dilated

    Green MYH6 in Fetal anomalies


    Version 1.576

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    Phenotypes
    • Atrial septal defect 3 (MIM#614089)
    • MYH-6 related congenital heart defects MONDO:0800442

    Red MYH6 in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 1.148

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category C gene
    • Expert Review Red
    Phenotypes
    • Cardiomyopathy, dilated
    • Cardiomyopathy, familial hypertrophic
    • Atrial septal defect