PMVK

phosphomevalonate kinase
OMIM: 607622, ClinGen, DECIPHER

4 panels

Panel Reviews Mode of inheritance Details
4 panels

Green PMVK in Ichthyosis and Porokeratosis


Level 2: Dermatological disorders
Version 1.22

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • porokeratosis 1, Mibelli type MONDO:0008290

Green PMVK in Mendeliome


Version 1.3795

1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert Review
Phenotypes
  • Porokeratosis 1, multiple types, MIM# 175800
  • Autoinflammatory syndrome, MONDO:0019751, PMVK-related

Green PMVK in Autoinflammatory Disorders


Level 2: Immunological disorders
Version 2.40

Component of the following Super Panels:

  • Immunological disorders_SuperPanel
  • 2 reviews BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Literature
    • Literature
    Phenotypes
    • Autoinflammatory syndrome, MONDO:0019751, PMVK-related

    Amber PMVK in Mosaic skin disorders


    Level 2: Dermatological disorders
    Version 1.15

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel
  • 1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • Genomics England PanelApp
    • NHS GMS
    Phenotypes
    • Linear porokeratosis
    • Porokeratosis 1, multiple types, MIM# 175800