PanelApp
  1. Genes and Genomic Entities
  2. RUNX1

RUNX1

RUNX family transcription factor 1
OMIM: 151385, ClinGen, DECIPHER

10 panels

Panel Reviews Mode of inheritance Details
10 panels

Green RUNX1 in Haematological malignancies


Level 2: Cancer susceptibility
Version 0.148

1 review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Curated sources
Phenotypes
  • Quantitative and qualitative platelet disorders with propensity to myeloid malignancy, Familial platelet disorder with propensity to myeloid malignancy
  • AML, MDS
  • Thrombocytopenia
  • No other known cancer risks
  • Class: familial predisp to leukaemia (typ AD)

Green RUNX1 in Bleeding and Platelet Disorders


Level 2: Haematological disorders
Version 2.1

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399

Green RUNX1 in Bone Marrow Failure


Level 2: Haematological disorders
Version 2.9

Component of the following Super Panels:

  • Immunological disorders_SuperPanel

    		•  1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399

    Green RUNX1 in Mendeliome


    Version 2.588

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399
    • Leukemia, acute myeloid, MIM# 601626

    Green RUNX1 in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 1.2

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Leukemia, acute myeloid, MIM# 601626

    Green RUNX1 in Additional findings_Adult


    Level 2: Screening
    Version 3.1

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399

    Green RUNX1 in Incidentalome_PREGEN_DRAFT


    Version 1.0

    		0 reviews Unknown
    Sources
    • NSW Health Pathology
    • Expert Review Green

    Green RUNX1 in IBMDx study


    Version 1.2

    		1 review Unknown
    Sources
    • Expert Review Green
    • IBMDx Study
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399

    Green RUNX1 in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 2.7

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • ClinGen
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399
    Tags
    • for review
    • treatable
    • haematological

    Green RUNX1 in Transplant Co-Morbidity


    Level 2: Screening
    Version 1.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert list
    • Expert Review Green
    Phenotypes
    • Platelet disorder, familial, with associated myeloid malignancy, MIM# 601399