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| Brugada syndrome v0.46 | FGF12 |
Sangavi Sivagnanasundram gene: FGF12 was added gene: FGF12 was added to Brugada syndrome. Sources: ClinGen Mode of inheritance for gene: FGF12 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: FGF12 were set to Brugada syndrome MONDO:0015263 Review for gene: FGF12 was set to RED Added comment: Classified as DISPUTED by ClinGen Hereditary Cardiovascular Disease GCEP on 15/01/2026 - https://search.clinicalgenome.org/CCID:009116 "Since the initial gene-disease assertion in 2013, there has been no further compelling genetic evidence corroborating this relationship. Indeed, two separate studies have specifically considered the prevalence of FGF12 variants in Brugada syndrome cohorts and have not found any rare variants within the coding exons of the gene. Given the absence of compelling clinical genetic data over a 13 year period, this gene-disease classification was disputed." Sources: ClinGen |
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