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Brugada syndrome v0.46 FGF12 Sangavi Sivagnanasundram gene: FGF12 was added
gene: FGF12 was added to Brugada syndrome. Sources: ClinGen
Mode of inheritance for gene: FGF12 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: FGF12 were set to Brugada syndrome MONDO:0015263
Review for gene: FGF12 was set to RED
Added comment: Classified as DISPUTED by ClinGen Hereditary Cardiovascular Disease GCEP on 15/01/2026 - https://search.clinicalgenome.org/CCID:009116

"Since the initial gene-disease assertion in 2013, there has been no further compelling genetic evidence corroborating this relationship. Indeed, two separate studies have specifically considered the prevalence of FGF12 variants in Brugada syndrome cohorts and have not found any rare variants within the coding exons of the gene. Given the absence of compelling clinical genetic data over a 13 year period, this gene-disease classification was disputed."
Sources: ClinGen
Brugada syndrome v0.45 Sangavi Sivagnanasundram Copied gene TMEM168 from panel Incidentalome
Brugada syndrome v0.45 TMEM168 Sangavi Sivagnanasundram gene: TMEM168 was added
gene: TMEM168 was added to Brugada syndrome. Sources: ClinGen
Mode of inheritance for gene: TMEM168 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: TMEM168 were set to https://search.clinicalgenome.org/CCID:009114
Phenotypes for gene: TMEM168 were set to Brugada syndrome MONDO:0015263
Brugada syndrome v0.44 SCN2B Chirag Patel Marked gene: SCN2B as ready
Brugada syndrome v0.44 SCN2B Chirag Patel Gene: scn2b has been classified as Red List (Low Evidence).
Brugada syndrome v0.44 TRPM4 Chirag Patel Marked gene: TRPM4 as ready
Brugada syndrome v0.44 TRPM4 Chirag Patel Gene: trpm4 has been classified as Red List (Low Evidence).
Brugada syndrome v0.44 SLMAP Chirag Patel Marked gene: SLMAP as ready
Brugada syndrome v0.44 SLMAP Chirag Patel Gene: slmap has been classified as Red List (Low Evidence).
Brugada syndrome v0.44 PKP2 Chirag Patel Marked gene: PKP2 as ready
Brugada syndrome v0.44 PKP2 Chirag Patel Gene: pkp2 has been classified as Red List (Low Evidence).
Brugada syndrome v0.44 KCNE5 Chirag Patel Mode of inheritance for gene: KCNE5 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to X-LINKED: hemizygous mutation in males, biallelic mutations in females
Brugada syndrome v0.43 KCNE5 Chirag Patel Deleted their comment
Brugada syndrome v0.43 KCNE5 Chirag Patel edited their review of gene: KCNE5: Added comment: ClinGen DISPUTED - Nov 2017; Changed mode of inheritance: X-LINKED: hemizygous mutation in males, biallelic mutations in females
Brugada syndrome v0.43 KCNE5 Chirag Patel Marked gene: KCNE5 as ready
Brugada syndrome v0.43 KCNE5 Chirag Patel Gene: kcne5 has been classified as Red List (Low Evidence).
Brugada syndrome v0.43 HCN4 Chirag Patel Marked gene: HCN4 as ready
Brugada syndrome v0.43 HCN4 Chirag Patel Gene: hcn4 has been classified as Red List (Low Evidence).
Brugada syndrome v0.43 ANK2 Chirag Patel Marked gene: ANK2 as ready
Brugada syndrome v0.43 ANK2 Chirag Patel Gene: ank2 has been classified as Red List (Low Evidence).
Brugada syndrome v0.43 PKP2 Chirag Patel gene: PKP2 was added
gene: PKP2 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: PKP2.
Mode of inheritance for gene: PKP2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PKP2 were set to Brugada syndrome, MONDO:0015263
Review for gene: PKP2 was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.43 SLMAP Chirag Patel gene: SLMAP was added
gene: SLMAP was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: SLMAP.
Mode of inheritance for gene: SLMAP was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: SLMAP were set to Brugada syndrome, MONDO:0015263
Review for gene: SLMAP was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.43 SCN2B Chirag Patel gene: SCN2B was added
gene: SCN2B was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: SCN2B.
Mode of inheritance for gene: SCN2B was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: SCN2B were set to Brugada syndrome, MONDO:0015263
Review for gene: SCN2B was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.43 TRPM4 Chirag Patel gene: TRPM4 was added
gene: TRPM4 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: TRPM4.
Mode of inheritance for gene: TRPM4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: TRPM4 were set to Brugada syndrome, MONDO:0015263
Review for gene: TRPM4 was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.42 KCNE5 Chirag Patel gene: KCNE5 was added
gene: KCNE5 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: KCNE5.
Mode of inheritance for gene: KCNE5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: KCNE5 were set to Brugada syndrome, MONDO:0015263
Review for gene: KCNE5 was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.42 HCN4 Chirag Patel gene: HCN4 was added
gene: HCN4 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: HCN4.
Mode of inheritance for gene: HCN4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: HCN4 were set to Brugada syndrome, MONDO:0015263
Review for gene: HCN4 was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.42 ANK2 Chirag Patel gene: ANK2 was added
gene: ANK2 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: ANK2.
Mode of inheritance for gene: ANK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: ANK2 were set to Brugada syndrome, MONDO:0015263
Review for gene: ANK2 was set to RED
Added comment: ClinGen DISPUTED - Nov 2017
Sources: ClinGen
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.41 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.40 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.40 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from Brugada syndrome, MONDO:0015263 to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.40 KCNE3 Chirag Patel Phenotypes for gene: KCNE3 were changed from to Brugada syndrome, MONDO:0015263
Brugada syndrome v0.39 CACNA2D1 Chirag Patel Phenotypes for gene: CACNA2D1 were changed from to Brugada syndrome 1, MONDO:0011001
Brugada syndrome v0.38 KCNJ8 Chirag Patel Phenotypes for gene: KCNJ8 were changed from Brugada syndrome 1, MONDO:0011001 to Brugada syndrome 1, MONDO:0011001
Brugada syndrome v0.38 KCNJ8 Chirag Patel Phenotypes for gene: KCNJ8 were changed from Brugada syndrome to Brugada syndrome 1, MONDO:0011001
Brugada syndrome v0.37 SCN1B Chirag Patel Phenotypes for gene: SCN1B were changed from Brugada syndrome 1, MONDO:0011001 to Brugada syndrome 1, MONDO:0011001
Brugada syndrome v0.37 SCN1B Chirag Patel Phenotypes for gene: SCN1B were changed from to Brugada syndrome 1, MONDO:0011001
Brugada syndrome v0.36 KCNH2 Chirag Patel Marked gene: KCNH2 as ready
Brugada syndrome v0.36 KCNH2 Chirag Patel Gene: kcnh2 has been classified as Red List (Low Evidence).
Brugada syndrome v0.36 ABCC9 Chirag Patel Marked gene: ABCC9 as ready
Brugada syndrome v0.36 ABCC9 Chirag Patel Gene: abcc9 has been classified as Red List (Low Evidence).
Brugada syndrome v0.36 ABCC9 Chirag Patel gene: ABCC9 was added
gene: ABCC9 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: ABCC9.
Mode of inheritance for gene: ABCC9 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: ABCC9 were set to Brugada syndrome, MONDO:0015263
Review for gene: ABCC9 was set to RED
Added comment: ClinGen DISPUTED - Oct 2025
Sources: ClinGen
Brugada syndrome v0.36 KCNH2 Chirag Patel gene: KCNH2 was added
gene: KCNH2 was added to Brugada syndrome. Sources: ClinGen
disputed tags were added to gene: KCNH2.
Mode of inheritance for gene: KCNH2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: KCNH2 were set to Brugada syndrome, MONDO:0015263
Review for gene: KCNH2 was set to RED
Added comment: ClinGen DISPUTED - Jun 2025
Sources: ClinGen
Brugada syndrome v0.35 RANGRF Chirag Patel Marked gene: RANGRF as ready
Brugada syndrome v0.35 RANGRF Chirag Patel Gene: rangrf has been classified as Red List (Low Evidence).
Brugada syndrome v0.35 RANGRF Chirag Patel gene: RANGRF was added
gene: RANGRF was added to Brugada syndrome. Sources: ClinGen
refuted tags were added to gene: RANGRF.
Mode of inheritance for gene: RANGRF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: RANGRF were set to Brugada syndrome, MONDO:0015263
Review for gene: RANGRF was set to RED
Added comment: ClinGen REFUTED - Oct 2025
Sources: ClinGen
Brugada syndrome v0.34 KCND3 Zornitza Stark Phenotypes for gene: KCND3 were changed from to Brugada syndrome
Brugada syndrome v0.33 KCND3 Zornitza Stark Tag disputed tag was added to gene: KCND3.
Brugada syndrome v0.33 CACNB2 Zornitza Stark Tag disputed tag was added to gene: CACNB2.
Brugada syndrome v0.33 CACNA2D1 Zornitza Stark Tag disputed tag was added to gene: CACNA2D1.
Brugada syndrome v0.33 CACNA1C Zornitza Stark Tag disputed tag was added to gene: CACNA1C.
Brugada syndrome v0.33 GPD1L Zornitza Stark Publications for gene: GPD1L were set to 17967977; 19666841
Brugada syndrome v0.32 GPD1L Zornitza Stark Classified gene: GPD1L as Red List (low evidence)
Brugada syndrome v0.32 GPD1L Zornitza Stark Gene: gpd1l has been classified as Red List (Low Evidence).
Brugada syndrome v0.31 SCN1B Zornitza Stark Marked gene: SCN1B as ready
Brugada syndrome v0.31 SCN1B Zornitza Stark Gene: scn1b has been classified as Red List (Low Evidence).
Brugada syndrome v0.31 SCN1B Zornitza Stark Publications for gene: SCN1B were set to
Brugada syndrome v0.30 SCN1B Zornitza Stark Classified gene: SCN1B as Red List (low evidence)
Brugada syndrome v0.30 SCN1B Zornitza Stark Gene: scn1b has been classified as Red List (Low Evidence).
Brugada syndrome v0.29 SCN1B Zornitza Stark Tag disputed tag was added to gene: SCN1B.
Brugada syndrome v0.29 SCN10A Zornitza Stark Marked gene: SCN10A as ready
Brugada syndrome v0.29 SCN10A Zornitza Stark Gene: scn10a has been classified as Red List (Low Evidence).
Brugada syndrome v0.29 SCN10A Zornitza Stark Phenotypes for gene: SCN10A were changed from to Brugada syndrome
Brugada syndrome v0.28 SCN10A Zornitza Stark Publications for gene: SCN10A were set to
Brugada syndrome v0.27 SCN10A Zornitza Stark Classified gene: SCN10A as Red List (low evidence)
Brugada syndrome v0.27 SCN10A Zornitza Stark Gene: scn10a has been classified as Red List (Low Evidence).
Brugada syndrome v0.26 SCN10A Zornitza Stark Tag disputed tag was added to gene: SCN10A.
Brugada syndrome v0.26 KCNJ8 Zornitza Stark Phenotypes for gene: KCNJ8 were changed from to Brugada syndrome
Brugada syndrome v0.25 KCNJ8 Zornitza Stark Marked gene: KCNJ8 as ready
Brugada syndrome v0.25 KCNJ8 Zornitza Stark Gene: kcnj8 has been classified as Red List (Low Evidence).
Brugada syndrome v0.25 KCNJ8 Zornitza Stark Tag disputed tag was added to gene: KCNJ8.
Brugada syndrome v0.25 KCNJ8 Zornitza Stark Publications for gene: KCNJ8 were set to
Brugada syndrome v0.24 KCNJ8 Zornitza Stark Classified gene: KCNJ8 as Red List (low evidence)
Brugada syndrome v0.24 KCNJ8 Zornitza Stark Gene: kcnj8 has been classified as Red List (Low Evidence).
Brugada syndrome v0.23 KCNE3 Zornitza Stark Marked gene: KCNE3 as ready
Brugada syndrome v0.23 KCNE3 Zornitza Stark Gene: kcne3 has been classified as Red List (Low Evidence).
Brugada syndrome v0.23 KCNE3 Zornitza Stark Tag disputed tag was added to gene: KCNE3.
Brugada syndrome v0.23 KCNE3 Zornitza Stark Publications for gene: KCNE3 were set to
Brugada syndrome v0.22 KCNE3 Zornitza Stark Classified gene: KCNE3 as Red List (low evidence)
Brugada syndrome v0.22 KCNE3 Zornitza Stark Gene: kcne3 has been classified as Red List (Low Evidence).
Brugada syndrome v0.21 KCND3 Zornitza Stark Marked gene: KCND3 as ready
Brugada syndrome v0.21 KCND3 Zornitza Stark Gene: kcnd3 has been classified as Red List (Low Evidence).
Brugada syndrome v0.21 KCND3 Zornitza Stark Publications for gene: KCND3 were set to
Brugada syndrome v0.20 KCND3 Zornitza Stark Classified gene: KCND3 as Red List (low evidence)
Brugada syndrome v0.20 KCND3 Zornitza Stark Gene: kcnd3 has been classified as Red List (Low Evidence).
Brugada syndrome v0.19 CACNB2 Zornitza Stark Marked gene: CACNB2 as ready
Brugada syndrome v0.19 CACNB2 Zornitza Stark Gene: cacnb2 has been classified as Red List (Low Evidence).
Brugada syndrome v0.19 CACNB2 Zornitza Stark Publications for gene: CACNB2 were set to
Brugada syndrome v0.18 CACNB2 Zornitza Stark Classified gene: CACNB2 as Red List (low evidence)
Brugada syndrome v0.18 CACNB2 Zornitza Stark Gene: cacnb2 has been classified as Red List (Low Evidence).
Brugada syndrome v0.17 CACNA2D1 Zornitza Stark Marked gene: CACNA2D1 as ready
Brugada syndrome v0.17 CACNA2D1 Zornitza Stark Gene: cacna2d1 has been classified as Red List (Low Evidence).
Brugada syndrome v0.17 CACNA2D1 Zornitza Stark Publications for gene: CACNA2D1 were set to
Brugada syndrome v0.16 CACNA2D1 Zornitza Stark Classified gene: CACNA2D1 as Red List (low evidence)
Brugada syndrome v0.16 CACNA2D1 Zornitza Stark Gene: cacna2d1 has been classified as Red List (Low Evidence).
Brugada syndrome v0.15 CACNA1C Zornitza Stark Marked gene: CACNA1C as ready
Brugada syndrome v0.15 CACNA1C Zornitza Stark Gene: cacna1c has been classified as Red List (Low Evidence).
Brugada syndrome v0.15 CACNA1C Zornitza Stark Publications for gene: CACNA1C were set to
Brugada syndrome v0.14 CACNA1C Zornitza Stark Classified gene: CACNA1C as Red List (low evidence)
Brugada syndrome v0.14 CACNA1C Zornitza Stark Gene: cacna1c has been classified as Red List (Low Evidence).
Brugada syndrome v0.13 SCN3B Ivan Macciocca reviewed gene: SCN3B: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: Brugada syndrome; Mode of inheritance: None
Brugada syndrome v0.13 GPD1L Ivan Macciocca reviewed gene: GPD1L: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 SCN5A Ivan Macciocca reviewed gene: SCN5A: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: Brugada syndrome; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Brugada syndrome v0.13 SCN1B Ivan Macciocca reviewed gene: SCN1B: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 SCN10A Ivan Macciocca reviewed gene: SCN10A: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 KCNJ8 Ivan Macciocca reviewed gene: KCNJ8: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 KCNE3 Ivan Macciocca reviewed gene: KCNE3: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 CACNB2 Ivan Macciocca changed review comment from: disputed by ClinGen (21/11/2017) and recent publication: Circulation. 2018;138:1195–1205 (PMID: 29959160); to: disputed by ClinGen (21/11/2017) and as reported in Circulation. 2018;138:1195–1205 (PMID: 29959160)
Brugada syndrome v0.13 CACNA2D1 Ivan Macciocca changed review comment from: disputed by ClinGen (21/11/2017) and recent publication: Circulation. 2018;138:1195–1205; to: disputed by ClinGen (21/11/2017) and as reported in Circulation. 2018;138:1195–1205 (PMID: 29959160)
Brugada syndrome v0.13 CACNA1C Ivan Macciocca changed review comment from: disputed by ClinGen (21/11/2017) and recent publication: Circulation. 2018;138:1195–1205; to: disputed by ClinGen (21/11/2017) and as reported in Circulation. 2018;138:1195–1205 (PMID: 29959160)
Brugada syndrome v0.13 KCND3 Ivan Macciocca reviewed gene: KCND3: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 CACNB2 Ivan Macciocca reviewed gene: CACNB2: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 CACNA2D1 Ivan Macciocca reviewed gene: CACNA2D1: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 CACNA1C Ivan Macciocca reviewed gene: CACNA1C: Rating: RED; Mode of pathogenicity: None; Publications: PMID: 29959160; Phenotypes: ; Mode of inheritance: None
Brugada syndrome v0.13 SCN3B Zornitza Stark Phenotypes for gene: SCN3B were changed from Brugada syndrome 7 MIM#613120 to Brugada syndrome 7 MIM#613120
Brugada syndrome v0.13 SCN3B Zornitza Stark Marked gene: SCN3B as ready
Brugada syndrome v0.13 SCN3B Zornitza Stark Gene: scn3b has been classified as Red List (Low Evidence).
Brugada syndrome v0.13 SCN3B Zornitza Stark Phenotypes for gene: SCN3B were changed from to Brugada syndrome 7 MIM#613120
Brugada syndrome v0.12 SCN3B Zornitza Stark Mode of inheritance for gene: SCN3B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Brugada syndrome v0.11 SCN3B Zornitza Stark Classified gene: SCN3B as Red List (low evidence)
Brugada syndrome v0.11 SCN3B Zornitza Stark Gene: scn3b has been classified as Red List (Low Evidence).
Brugada syndrome v0.10 SCN3B Zornitza Stark Tag disputed tag was added to gene: SCN3B.
Brugada syndrome v0.10 GPD1L Zornitza Stark Marked gene: GPD1L as ready
Brugada syndrome v0.10 GPD1L Zornitza Stark Added comment: Comment when marking as ready: Rated as DISPUTED by ClinGen.
Brugada syndrome v0.10 GPD1L Zornitza Stark Gene: gpd1l has been classified as Amber List (Moderate Evidence).
Brugada syndrome v0.10 GPD1L Zornitza Stark Phenotypes for gene: GPD1L were changed from to Brugada syndrome 2, MIM# 611777
Brugada syndrome v0.9 GPD1L Zornitza Stark Publications for gene: GPD1L were set to
Brugada syndrome v0.8 GPD1L Zornitza Stark Mode of inheritance for gene: GPD1L was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Brugada syndrome v0.7 GPD1L Zornitza Stark Tag disputed tag was added to gene: GPD1L.
Brugada syndrome v0.7 GPD1L Zornitza Stark Classified gene: GPD1L as Amber List (moderate evidence)
Brugada syndrome v0.7 GPD1L Zornitza Stark Gene: gpd1l has been classified as Amber List (Moderate Evidence).
Brugada syndrome v0.6 GPD1L Elena Savva reviewed gene: GPD1L: Rating: AMBER; Mode of pathogenicity: None; Publications: PMID: 17967977, 19666841; Phenotypes: Brugada syndrome 2 611777; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Brugada syndrome v0.6 SCN3B Bryony Thompson reviewed gene: SCN3B: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: Brugada syndrome 7 MIM#613120; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Brugada syndrome v0.6 SCN5A Zornitza Stark Marked gene: SCN5A as ready
Brugada syndrome v0.6 SCN5A Zornitza Stark Gene: scn5a has been classified as Green List (High Evidence).
Brugada syndrome v0.6 SCN5A Zornitza Stark Phenotypes for gene: SCN5A were changed from to Atrial fibrillation, familial, 10; Brugada syndrome 1; Cardiomyopathy, dilated, 1E; Heart block, nonprogressive; Heart block, progressive, type IA; Long QT syndrome 3; Sick sinus syndrome 1; Ventricular fibrillation, familial, 1; {Sudden infant death syndrome, susceptibility to}
Brugada syndrome v0.6 SCN5A Zornitza Stark Publications for gene: SCN5A were set to
Brugada syndrome v0.5 SCN5A Zornitza Stark Mode of pathogenicity for gene: SCN5A was changed from to Other
Brugada syndrome v0.5 SCN5A Zornitza Stark Mode of inheritance for gene: SCN5A was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Brugada syndrome v0.4 SCN5A Elena Savva reviewed gene: SCN5A: Rating: GREEN; Mode of pathogenicity: Other; Publications: PMID: 29806494, 18929244; Phenotypes: Atrial fibrillation, familial, 10, Brugada syndrome 1, Cardiomyopathy, dilated, 1E, Heart block, nonprogressive, Heart block, progressive, type IA, Long QT syndrome 3, Sick sinus syndrome 1, Ventricular fibrillation, familial, 1, {Sudden infant death syndrome, susceptibility to}; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Brugada syndrome v0.4 Zornitza Stark Panel types changed to Victorian Clinical Genetics Services; Rare Disease
Brugada syndrome v0.2 Zornitza Stark Panel name changed from Brugada syndrome_VCGS to Brugada syndrome
Brugada syndrome v0.1 Zornitza Stark Panel types changed to Victorian Clinical Genetics Services
Brugada syndrome v0.0 SCN5A Zornitza Stark gene: SCN5A was added
gene: SCN5A was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: SCN5A was set to Unknown
Brugada syndrome v0.0 SCN3B Zornitza Stark gene: SCN3B was added
gene: SCN3B was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: SCN3B was set to Unknown
Brugada syndrome v0.0 SCN1B Zornitza Stark gene: SCN1B was added
gene: SCN1B was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: SCN1B was set to Unknown
Brugada syndrome v0.0 SCN10A Zornitza Stark gene: SCN10A was added
gene: SCN10A was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: SCN10A was set to Unknown
Brugada syndrome v0.0 KCNJ8 Zornitza Stark gene: KCNJ8 was added
gene: KCNJ8 was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: KCNJ8 was set to Unknown
Brugada syndrome v0.0 KCNE3 Zornitza Stark gene: KCNE3 was added
gene: KCNE3 was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: KCNE3 was set to Unknown
Brugada syndrome v0.0 KCND3 Zornitza Stark gene: KCND3 was added
gene: KCND3 was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: KCND3 was set to Unknown
Brugada syndrome v0.0 GPD1L Zornitza Stark gene: GPD1L was added
gene: GPD1L was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: GPD1L was set to Unknown
Brugada syndrome v0.0 CACNB2 Zornitza Stark gene: CACNB2 was added
gene: CACNB2 was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: CACNB2 was set to Unknown
Brugada syndrome v0.0 CACNA2D1 Zornitza Stark gene: CACNA2D1 was added
gene: CACNA2D1 was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: CACNA2D1 was set to Unknown
Brugada syndrome v0.0 CACNA1C Zornitza Stark gene: CACNA1C was added
gene: CACNA1C was added to Brugada syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: CACNA1C was set to Unknown
Brugada syndrome v0.0 Zornitza Stark Added panel Brugada syndrome_VCGS