HCN4

hyperpolarization activated cyclic nucleotide gated potassium channel 4
OMIM: 605206, ClinGen, DECIPHER

9 panels

Panel Reviews Mode of inheritance Details
9 panels

Amber HCN4 in Aortopathy_Connective Tissue Disorders


Level 2: Cardiovascular disorders
Version 1.101

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • ClinGen
Phenotypes
  • Sick sinus syndrome 2 with cardiac noncompaction and ascending aorta dilation

Red HCN4 in Brugada syndrome


Level 2: Cardiovascular disorders
Version 0.44

Component of the following Super Panels:

  • Adult Cardiac SuperPanel
  • Arrhythmia_SuperPanel
  • 1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • ClinGen
    Phenotypes
    • Brugada syndrome, MONDO:0015263
    Tags
    • disputed

    Green HCN4 in Incidentalome


    Version 0.368

    2 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • ClinGen
    • Victorian Clinical Genetics Services
    Phenotypes
    • Sick sinus syndrome 2, MIM# 163800
    • Aortopathy
    Tags
    • cardiac

    Red HCN4 in Genetic Epilepsy


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.307

    Component of the following Super Panels:

  • Progressive Neurological Conditions
  • 1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • {Epilepsy, idiopathic generalized, susceptibility to, 18}, MIM# 619521

    Green HCN4 in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.208

    0 reviews MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS

    Red HCN4 in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • BabySeq Category C gene
    Phenotypes
    • Brugada syndrome

    Red HCN4 in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 1.141

    0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category C gene
    • Expert Review Red
    Phenotypes
    • Brugada syndrome

    Green HCN4 in Transplant Co-Morbidity


    Level 2: Screening
    Version 0.20

    0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Sick sinus syndrome 2, MIM# 163800

    Green HCN4 in Cardiac conduction disease


    Level 2: Cardiovascular disorders
    Version 1.5

    Component of the following Super Panels:

  • Adult Cardiac SuperPanel
  • Arrhythmia_SuperPanel
  • 2 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • NHS GMS
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Sick sinus syndrome MONDO:0001823