LGR4

leucine rich repeat containing G protein-coupled receptor 4
OMIM: 606666, ClinGen, DECIPHER

3 panels

Panel Reviews Mode of inheritance Details
3 panels

Amber LGR4 in Mendeliome


Version 2.362

2 reviews BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Victorian Clinical Genetics Services
Phenotypes
  • {Bone mineral density, low, susceptibility to} MIM#615311
  • Syndromic disease, LGR4-related (MONDO#0002254)
  • Delayed puberty, self-limited, MONDO:0859205

Red LGR4 in Pituitary hormone deficiency

Level 3: Pituitary disorders
Level 2: Endocrine disorders
Version 1.18

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Delayed puberty, self-limited, MONDO:0859205

Red LGR4 in Hypogonadotropic hypogonadism

Level 3: Pituitary disorders
Level 2: Endocrine disorders
Version 1.15

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Delayed puberty, self-limited, MONDO:0859205