PanelApp
  1. Genes and Genomic Entities
  2. MRE11

MRE11

MRE11 homolog, double strand break repair nuclease
OMIM: 600814, ClinGen, DECIPHER

11 panels

Panel Reviews Mode of inheritance Details
11 panels

Green MRE11 in Chromosome Breakage Disorders


Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.24

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Ataxia-telangiectasia-like disorder 1, MIM# 604391
  • MONDO:0024557

Green MRE11 in Mendeliome


Version 1.3795

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Ataxia-telangiectasia-like disorder 1, MIM# 604391
  • MONDO:0024557

Amber MRE11 in Microcephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.375

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Victorian Clinical Genetics Services
Phenotypes
  • Nijmegen breakage syndrome-like severe microcephaly

Green MRE11 in Regression


Level 2: Neurology and neurodevelopmental disorders
Version 0.600

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green MRE11 in Homologous_recombination_deficiency_WTS_UMCCR


Level 2: Cancer
Version 0.45

0 reviews Unknown
Sources
  • Literature
  • Expert Review Green
Tags
  • umccr

Green MRE11 in Ataxia


Level 2: Neurology and neurodevelopmental disorders
Version 1.158

Component of the following Super Panels:

  • Neuromuscular Superpanel
  • Progressive Neurological Conditions

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Royal Melbourne Hospital
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Ataxia-Telangiectasia-Like Disorder
    • Ataxia-telangiectasia-like disorder 1, 604391

    Green MRE11 in Mackenzie's Mission_Reproductive Carrier Screening


    Level 2: Screening
    Version 0.111

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Ataxia-telangiectasia-like disorder, 604391 (3)

    Green MRE11 in Prepair 1000+


    Level 2: Screening
    Version 2.15

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Ataxia-telangiectasia-like disorder, 604391 (3)

    Green MRE11 in Prepair 500+


    Level 2: Screening
    Version 2.0

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Ataxia-telangiectasia-like disorder, MIM#604391

    Red MRE11 in Ovarian Cancer


    Level 2: Cancer Predisposition
    Version 1.6

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • ClinGen
    Phenotypes
    • Familial ovarian cancer, MONDO:0016248
    Tags
    • refuted

    Red MRE11 in Breast Cancer


    Level 2: Cancer Predisposition
    Version 1.18

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • ClinGen
    Phenotypes
    • Hereditary breast carcinoma, MONDO:0016419
    Tags
    • refuted