PanelApp
  1. Genes and Genomic Entities
  2. SCN10A

SCN10A

sodium voltage-gated channel alpha subunit 10
OMIM: 604427, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels

Red SCN10A in Brugada syndrome


Level 2: Cardiovascular disorders
Version 0.34

Component of the following Super Panels:

  • Adult Cardiac SuperPanel
  • Arrhythmia_SuperPanel

    		•  1 review Unknown
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services
    Phenotypes
    • Brugada syndrome
    Tags
    • disputed

    Green SCN10A in Mendeliome


    Version 1.3499

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Episodic pain syndrome, familial, 2, MIM# 615551

    Red SCN10A in Genetic Epilepsy


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.263

    Component of the following Super Panels:

  • Progressive Neurological Conditions

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Literature
    Phenotypes
    • Episodic pain syndrome, familial, 2 MIM#615551
    • Neurodevelopmental disorder (MONDO#0700092), SCN10A-related

    Green SCN10A in Hereditary Neuropathy_CMT - isolated


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.68

    Component of the following Super Panels:

  • Hereditary Neuropathy_CMT_IsolatedAndComplex
  • Neuromuscular Superpanel
  • Progressive Neurological Conditions

    		•  1 review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Royal Melbourne Hospital
    Phenotypes
    • HSAN/SFN
    • Episodic pain syndrome, familial, 2, 615551

    Green SCN10A in Pain syndromes


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.36

    Component of the following Super Panels:

  • Progressive Neurological Conditions

    		•  1 review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    Phenotypes
    • Small fibre neuropathy
    • Episodic pain syndrome, familial, 2, MIM# 615551