PanelApp
  1. Genes and Genomic Entities
  2. FANCL

FANCL

FA complementation group L
OMIM: 608111, ClinGen, DECIPHER

19 panels

Panel Reviews Mode of inheritance Details
19 panels

Green FANCL in Haematological malignancies


Level 2: Cancer susceptibility
Version 0.148

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Curated sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Bone marrow failure
  • MDS
  • Fanconi anemia
  • AML
  • Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
  • Class: BM failure FA, (typ AR)

Green FANCL in Bone Marrow Failure


Level 2: Haematological disorders
Version 2.9

Component of the following Super Panels:

  • Immunological disorders_SuperPanel

    		•  2 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Chromosome Breakage Disorders


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 2.3

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Mendeliome


    Version 2.588

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Microcephaly


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 2.32

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083

    Green FANCL in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 1.2

    		0 reviews Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Green FANCL in Radial Ray Abnormalities


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 2.0

    Component of the following Super Panels:

  • Limb and Digital Malformations SuperPanel

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Additional findings_Adult


    Level 2: Screening
    Version 3.1

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Fanconi anaemia, complementation group L, MIM# 614083

    Green FANCL in Homologous_recombination_deficiency_WTS_UMCCR


    Level 2: Cancer
    Version 1.0

    		0 reviews Unknown
    Sources
    • Literature
    • Expert Review Green
    Tags
    • umccr

    Green FANCL in Mackenzie's Mission_Reproductive Carrier Screening


    Level 2: Screening
    Version 1.0

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Fanconi anemia, complementation group L, 614083 (3)

    Amber FANCL in Primary Ovarian Insufficiency_Premature Ovarian Failure

    Level 3: Gonadal and sex development disorders
    Level 2: Endocrine disorders
    Version 1.4

    		1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Primary ovarian insufficiency
    • Fanconi anemia, complementation group L MIM#614083

    Red FANCL in Additional findings_Paediatric


    Level 2: Screening
    Version 1.1

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • BabySeq Category C gene
    Phenotypes
    • Fanconi anaemia

    Red FANCL in Clefting disorders

    Level 3: Dysmorphic disorders
    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.25

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Radboud University Medical Center, Nijmegen
    • UKGTN
    • Illumina TruGenome Clinical Sequencing Services
    • Expert list
    Phenotypes
    • Fanconi anemia, complementation group L, 614083

    Green FANCL in Growth failure


    Version 2.28

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Fetal anomalies


    Version 2.81

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, OMIM:614083
    • Fanconi anemia complementation group L, MONDO:0013566

    Green FANCL in IBMDx study


    Version 1.2

    		1 review Unknown
    Sources
    • Expert Review Green
    • IBMDx Study
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Fanconi anemia, complementation group L, MIM# 614083
    • MONDO:0013566

    Green FANCL in Prepair 1000+


    Level 2: Screening
    Version 3.0

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Fanconi anaemia, complementation group L MIM#614083

    Red FANCL in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 2.7

    		0 reviews BIALLELIC, autosomal or pseudoautosomal
    Sources
    • BabySeq Category C gene
    • Expert Review Red
    • BeginNGS
    Phenotypes
    • Fanconi anaemia
    • Fanconi anaemia, MIM#614083

    Green FANCL in Prepair 500+


    Level 2: Screening
    Version 3.0

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Mackenzie's Mission
    Phenotypes
    • Fanconi anaemia, complementation group L MIM#614083