PanelApp
  1. Genes and Genomic Entities
  2. SCN1B

SCN1B

sodium voltage-gated channel beta subunit 1
OMIM: 600235, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels

Red SCN1B in Brugada syndrome


Level 2: Cardiovascular disorders
Version 0.34

Component of the following Super Panels:

  • Adult Cardiac SuperPanel
  • Arrhythmia_SuperPanel

    		•  review Unknown
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services
    Tags
    • disputed

    Green SCN1B in Incidentalome


    Version 0.314

    		review Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Green SCN1B in Genetic Epilepsy


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.119

    Component of the following Super Panels:

  • Progressive Neurological Conditions

    		•  review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Australian Genomics Health Alliance Epilepsy Flagship
    Phenotypes
    • Developmental and epileptic encephalopathy (MONDO:0100062)
    • generalized epilepsy with febrile seizures plus (MONDO:0018214)

    Green SCN1B in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.83

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genetic Health Queensland
    Phenotypes
    • Epileptic encephalopathy, early infantile, 52, MIM#617350

    Red SCN1B in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • BabySeq Category C gene
    Phenotypes
    • Brugada syndrome

    Red SCN1B in Fetal anomalies


    Version 1.314

    		review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Genomics England PanelApp
    • Genetic Health Queensland
    Phenotypes
    • Epileptic encephalopathy, early infantile, 52, MIM#617350
    • Atrial fibrillation, familial, 13, MIM# 615377

    No list SCN1B in Prepair 1000+


    Level 2: Screening
    Version 1.1586

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Literature
    Phenotypes
    • Developmental and epileptic encephalopathy 52, MIM#617350

    Red SCN1B in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.116

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category C gene
    • Expert Review Red
    Phenotypes
    • Brugada syndrome