Genes in panel
Regions in panel
Prev Next

Mendeliome

Gene: MRAP2

Amber List (moderate evidence)

MRAP2 (melanocortin 2 receptor accessory protein 2)
EnsemblGeneIds (GRCh38): ENSG00000135324
EnsemblGeneIds (GRCh37): ENSG00000135324
OMIM: 615410, Gene2Phenotype
MRAP2 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Multiple studies supporting association between rare variants and obesity; however ?monogenic vs susceptibility alleles.
Sources: Literature
Created: 4 Feb 2025, 3:16 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Susceptibility to obesity, MIM#615457

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Literature
Phenotypes
  • Susceptibility to obesity, MIM#615457
OMIM
615410
Clinvar variants
Variants in MRAP2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

4 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mrap2 has been classified as Amber List (Moderate Evidence).

4 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mrap2 has been classified as Amber List (Moderate Evidence).

4 Feb 2025, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MRAP2 was added gene: MRAP2 was added to Mendeliome. Sources: Literature Mode of inheritance for gene: MRAP2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MRAP2 were set to 23869016; 31700171; 27474872; 26795956 Phenotypes for gene: MRAP2 were set to Susceptibility to obesity, MIM#615457 Review for gene: MRAP2 was set to AMBER