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Mendeliome

Gene: MEG3

Green List (high evidence)

MEG3 (maternally expressed 3 (non-protein coding))
EnsemblGeneIds (GRCh38): ENSG00000214548
EnsemblGeneIds (GRCh37): ENSG00000214548
OMIM: 605636, Gene2Phenotype
MEG3 is in 4 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Small deletions of MAG3 reported in multiple patients as one of the mechanisms of disease.
Sources: Literature
Created: 14 Mar 2025, 4:37 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)

Phenotypes
Kagami-Ogata syndrome, MIM# 608149

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Kagami-Ogata syndrome, MIM# 608149
Tags
SV/CNV non-coding gene
OMIM
605636
Clinvar variants
Variants in MEG3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Mar 2025, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: meg3 has been classified as Green List (High Evidence).

14 Mar 2025, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: meg3 has been classified as Green List (High Evidence).

14 Mar 2025, Gel status: 1

Created, Added New Source, Added Tag, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MEG3 was added gene: MEG3 was added to Mendeliome. Sources: Literature SV/CNV, non-coding gene tags were added to gene: MEG3. Mode of inheritance for gene: MEG3 was set to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed) Publications for gene: MEG3 were set to 33010492; 33746039; 33067531; 38212313 Phenotypes for gene: MEG3 were set to Kagami-Ogata syndrome, MIM# 608149 Review for gene: MEG3 was set to GREEN