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Mendeliome

Gene: LYRM7

Green List (high evidence)

LYRM7 (LYR motif containing 7)
EnsemblGeneIds (GRCh38): ENSG00000186687
EnsemblGeneIds (GRCh37): ENSG00000186687
OMIM: 615831, Gene2Phenotype
LYRM7 is in 7 panels

2 reviews

Sangavi Sivagnanasundram (Melbourne Health)

Green List (high evidence)

Update of ClinGen curation and publications.
Classified as DEFINITIVE by ClinGen mitochondrial disease GCEP on 04/04/2022 - https://search.clinicalgenome.org/CCID:005309
Created: 12 May 2025, 3:56 a.m. | Last Modified: 12 May 2025, 3:56 a.m.
Panel Version: 1.2588

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
mitochondrial disease, LYRM7-related MONDO:0044970

Publications

Krithika Murali (Victorian Clinical Genetics Services)

Green List (high evidence)

Well-established gene disease association
Created: 20 May 2022, 12:36 a.m. | Last Modified: 20 May 2022, 12:36 a.m.
Panel Version: 0.14660

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Mitochondrial complex III deficiency, nuclear type 8 - MIM#615838

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Victorian Clinical Genetics Services
Phenotypes
  • Mitochondrial complex III deficiency, nuclear type 8, MIM#615838
OMIM
615831
Clinvar variants
Variants in LYRM7
Penetrance
None
Panels with this gene

History Filter Activity

9 May 2022, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: lyrm7 has been classified as Green List (High Evidence).

9 May 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: LYRM7 were changed from to Mitochondrial complex III deficiency, nuclear type 8, MIM#615838

9 May 2022, Gel status: 3

Set mode of inheritance

Alison Yeung (Victorian Clinical Genetics Services)

Mode of inheritance for gene: LYRM7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LYRM7 was added gene: LYRM7 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: LYRM7 was set to Unknown